Approximately 23,000 HRS participants have been genotyped to date, with the most recent data released on the NIA Genetics of Alzheimer’s Disease Storage Site (NIAGADS). The HRS supplements core and supplemental survey collection with linkages to administrative records from Medicare and Social Security contextual data on participant living environments and biomarker data generated from saliva, dried blood spots, and, more recently, venous blood. The HRS collects core data in two-year intervals supplemented with off-year sub-studies using mixed modes of data collection. Cognitive and psycho-social factors on participants.Dimensions of economic status (e.g., income sources, wealth sources, housing, insurance, etc.).To achieve this objective, the HRS collects survey data related, but not limited, to the following topics: The objective of the HRS is to produce infrastructure to support multidisciplinary research on life course health and aging. Initiated in 1992, the Health and Retirement Study (HRS) is a longitudinal study that surveys a representative sample of approximately 20,000 people, aged 50 and older, in the United States via mixed-mode data collection. Additional content on social factors to study racial disparities and minority health via life histories, as well as the medium and long-term social impacts of the COVID-19 pandemic.Expanded aging and AD/ADRD-relevant blood-based biomarkers.Enhanced data on occupational exposures/characteristics.Improved overall response/retention rates to maintain representativeness.Contextual data to capture new elements of the exposome, ranging from microscopic to macro-level exposures.Larger samples of Black/African American and Hispanic/Latino populations in HCAP.This single integrated award combining HRS and HCAP seeks to implement recommendations from subject matter experts to enhance HRS/HCAP by adding the following: The HCAP includes a neuropsychological assessment battery as well as informant reports to better characterize cognitive function. In addition to the HRS, a companion study, the Harmonized Cognitive Assessment Protocol (HCAP), will be included as part of this application. The purpose of this FOA is to provide additional research opportunities to use HRS to formally study Alzheimer’s Disease (AD) and AD-Related Dementias (ADRD). The HRS is a longitudinal panel study that surveys a nationally representative sample of approximately 20,000 people, aged 50 and older, in the United States via mixed-mode data collection to support multidisciplinary research on life course health and aging. Therefore, this FOA is limited to investigators and institutions with access to the HRS sample frame, as the frame will be used to contact and collect new data from participants. Continuation of the study requires both knowledge of, and access to, the HRS sample frame. The purpose of this limited competition Funding Opportunity Announcement (FOA) is to continue data collection, development, and dissemination of the Health and Retirement Study (HRS).
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